The rap sheet for β-CTF is growing longer. The C-terminal fragment, produced when β-secretase cleaves APP, binds to—and blocks assembly of—vacuolar ATPase, a proton pump that fuels acidification of ...
Lysosomes require tight regulation of their pH to degrade their contents. Researchers know that V-ATPase pumps protons into these little digestive sacs, but what protein shuttles the ions back out?
The degradation of proteins and other macromolecules in cells is vital to survival. Disruption of this process can result in serious disease. The research group of Professor Thomas Jentsch (Leibniz ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results