Oogenesis is the process by which an ovarian germ cell becomes a female gamete, an egg. A functional egg is capable of undergoing fertilization and giving rise to a developing embryo, and it should ...

Since the effects of gender-affirming therapy on fertility are unknown, multiple medical societies endorse the preservation of fertility in persons who identify as transgender. 1-3 In transgender male ...

Explore the intricate relationship between ovarian reserve, egg quality, and reproductive aging. Discover how mitochondrial ...

Mammalian oocytes utilize a conserved combination of cell cycle control, cytoskeletal organization, and polarity pathways that are fundamentally shared with other vertebrates and invertebrates.

Females are born with a finite number of eggs that are steadily depleted throughout their lifetime. This reserve of eggs is selected from a much larger pool of millions of precursor cells, or oocytes, ...

In a new study published in the journal Nature, researchers in Japan report that activating just eight genes for producing gene-controlling proteins is enough to convert mouse stem cells directly into ...

Declining female fertility is a health issue that has received broad global attention. Oocyte quality is the key limiting factor of female fertility, and factors affecting oocyte quality involve the ...

Communication between oocytes and granulosa cells is essential for oocyte formation, dormancy, reawakening, and maturation. Researchers have demonstrated that a protein complex called the exocyst ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

Oocyte cryopreservation is a suitable fertility preservation option for women who are not partnered, have ethical objections to cryopreserving embryos or wish to have complete reproductive autonomy.

A joint research team led by Dr. Akira Kunitomi, a former postdoctoral fellow at CiRA (currently a researcher at the Gladstone Institute of Cardiovascular Disease), and ID Pharma Co., Ltd., has ...