Peptides offer a biodegradable, specific alternative to conventional pesticides, with the potential to address resistance and reduce harm to beneficial species. Here we argue that adopting the design ...

The discovery of macrocyclic peptide therapeutics has been slow. We introduce RFpeptides, a deep learning method that enables the de novo design of macrocyclic peptide binders to therapeutic targets.

By combining CRISPR knock-in with small peptide tags, researchers can study proteins in their native cellular context, ...

This schematic illustrates the AI-powered pipeline for designing novel antimicrobial peptides (AMPs). Through sequence and structure modeling, AI models enable rational design and de novo generation ...

When many of us think about how drugs work in the body, we may first think about how a drug gets into the body, such as a pill versus an injection. In the Gellman Group at the UW–Madison Department of ...

Researchers at the University of Bath, in collaboration with the Universities of Oxford and Bristol, have developed a molecule that prevents the clumping and build-up of a protein linked to ...

This study introduces a novel signal amplification method induced by aggregation, which achieves specific recognition and sensitive detection of two cancer biomarkers through the rational design of ...