By understanding how milligram to kilogram peptide production is achieved safely, drug developers can better navigate the ...

Chemical synthesis and peptide ligation techniques have revolutionised the field of protein engineering by enabling the precise construction of peptides and proteins with tailored modifications. These ...

Nature makes amide bonds—the key linkages that string together amino acids in a polypeptide—like a knitting whiz. The ribosome in Escherichia coli bacteria, for example, can make eight amide bonds in ...

Cyclic peptides offer enhanced stability and bioavailability, but precise cyclization strategies and specialized synthetic techniques are required to maintain their biological activity. A recent ...

A team at ETH Zurich developed a new peptide-based organocatalyst that handles macrocycle formation from start to finish.

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...

Discover how therapeutic peptides act as biological messengers to treat disease, improve metabolism, and enhance immune ...

The breakthrough could simplify the production of complex proteins used in cancer immunotherapy and other advanced medicines ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...