Why Growth Hormone Peptides Need to Be Taken on an Empty Stomach Your body has two signals that tell your pituitary gland to produce growth hormone: GHRH (during deep sleep or hard training) and ghrelin (when you’re fasted). Growth hormone secretagogues mimic these signals. But insulin binds directly to somatotrophs and suppresses growth hormone release. If you inject peptides while insulin is present, you’re pressing the gas and brake at the same time. Here’s where timing depends on your goal.
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